{"id":235,"date":"2015-10-14T09:00:49","date_gmt":"2015-10-14T09:00:49","guid":{"rendered":"http:\/\/projects.nyujournalism.org\/dormancy\/?page_id=235"},"modified":"2015-10-10T14:22:48","modified_gmt":"2015-10-10T14:22:48","slug":"the-sleeping-virus","status":"publish","type":"page","link":"http:\/\/projects.nyujournalism.org\/dormancy\/play-dead\/the-sleeping-virus\/","title":{"rendered":"The Sleeping Virus"},"content":{"rendered":"

Story by\u00a0Katherine Ellen Foley<\/em>
\nCover art by Steph Yin<\/em><\/p>\n

—<\/em><\/p>\n

In a sense, we\u2019re all just vessels for viruses.<\/span><\/p>\n

As you read this, you are probably carrying some kind of virus, even if you\u2019re not feeling sick. There\u2019s a good chance you\u2019re playing host to a strain of the common cold or flu, but as long as you\u2019re healthy overall, you won\u2019t even suffer a stuffy nose.<\/p>\n

When we do get sick, most of the time our bodies can fight off these infections in a few days. But alas, sometimes there are infections we can\u2019t shake \u2014 ever. These are the viruses that are able to go latent in our bodies. Without disturbing us, they lay in wait for the right moment when our defenses are down, and come back in full force.<\/p>\n

Viruses with the ability to go latent are relatively common, and most of them aren\u2019t too much of a health concern. Consider chickenpox<\/a>, a virus so common in kids it\u2019s almost like a rite of passage. Symptoms include telltale itchy pox and a fever, and usually leaves us unscathed. Later in life, though, it can cause shingles<\/a>, a painful outbreak of sores on our skin. Chickenpox and shingles are both caused by the same strain of a kind of herpes viruses (and there are vaccines for both).<\/p>\n

The idea of herpes may evoke thoughts of a sexually transmitted infection, but there are eight strains of this virus, the most common<\/a> of which is called herpes simplex one (HSV1). This virus causes cold sores, also known as fever blisters, on either your lips or genital area. But even though as many as 90 percent<\/a> of adults have HSV1, most people don\u2019t have cold sores all the time: This virus spends most of its time latent.<\/p>\n

\"nightmare-cartoon\"<\/a>So just how does HSV1 conduct its disappearing act?<\/p>\n

HSV1 can move from our outer layer of skin to our nervous system, according to Jay Brown<\/a>, a microbiologist at the University of Virginia. When we\u2019re first infected with the herpes virus, we may have an outbreak of cold sores as the virus infects the cells on our lips where it \u201creplicates like crazy,\u201d said\u00a0Bryan Cullen<\/a>, a microbiologist at Duke University. As the virus makes more and more copies of itself in our skin, we get lesions that look like fluid-filled pimples that itch and burn. After a few days to a week, these lesions disappear and leave us blemish-free. But that doesn\u2019t mean that the virus is gone from our bodies.<\/p>\n

While the superficial lesions\u00a0heal, the virus crawls (\u201cherpes\u201d likely came from the Greek word herpein, \u201cto creep\u201d<\/a>) up the nerves in our lips to a bundle of neurons called the trigeminal ganglion<\/a>. We have two of these groups of nerves located near each temple; they control the feeling and muscle movement in our faces. For reasons not entirely well understood, it stops here, and doesn\u2019t go any further. Like a bear entering hibernation, the virus discontinues pretty much all of its usual daily activities: No more reproducing, or making much of anything for that matter.<\/p>\n

\u201cThey actually don\u2019t produce any proteins at all during latency,\u201d Cullen said. \u201cThe virus sort of down-regulates its own ability to reactivate.\u201d It produces RNA, a type of simple genetic material, but this is likely to make sure it stays otherwise inactive. It\u2019s just waiting for the right moment to pounce.<\/p>\n

\"poorwill-cartoon\"<\/a><\/p>\n

It\u2019s hard to predict when HSV1 will wake up (there isn\u2019t a good animal model for studying it just yet) but when it does, it\u2019s annoyingly obvious. The cold sores on our faces re-appear, angry as ever \u2014 probably at an inopportune time. Cullen and UVA\u2019s Brown concur that physical<\/a> and possibly emotional<\/a> stress is a key factor driving repeat outbreaks. Something like a fever, sunburn or even a major presentation for work can restart the virus\u2019 engines. It can then inch back down our nerves to infect the same skin cells near our mouths.<\/p>\n

If you do have a fever blister, it\u2019s important not to share drinking classes or utensils, and kissing probably isn\u2019t the best idea: HSV1 can jump to a new host just from contact with skin. Some people experience frequent repeat outbreaks, while others may never experience one again.<\/p>\n

Fortunately, this virus isn\u2019t life-threatening in most healthy patients: It\u2019s more of a cosmetic annoyance than anything. A few days after the virus reemerges and erupts on our faces, it returns to laying in wait in our bodies, hiding from our immune systems, waiting for the right biological trigger to become active again.<\/p>\n

\u201cThe ideal thing the virus wants to do is grow and get passed on to the next host,\u201d said Brown. He says most viruses don\u2019t want to kill the host; the host has to stay alive so the virus can keep replicating. They just want to move on to the next one to keep their cycle of life going. So though we may think of ourselves as being evolutionarily superior with our multiple cells and organs, to a virus, we\u2019re just a big vehicle passing them along from one host to another.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Story by\u00a0Katherine Ellen Foley Cover art by Steph Yin — In a sense, we\u2019re all just vessels for viruses. As you read this, you are probably carrying some kind of virus, even if you\u2019re not feeling sick. There\u2019s a good chance you\u2019re playing host to a strain of the common cold or flu, but as […]<\/p>\n","protected":false},"author":4,"featured_media":746,"parent":27,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"acf":[],"yoast_head":"\nHerpes viruses can stay hidden for years - Dormancy<\/title>\n<meta name=\"description\" content=\"How one relatively harmless strain of a herpes virus bides its time in our bodies.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/projects.nyujournalism.org\/dormancy\/play-dead\/the-sleeping-virus\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Herpes viruses can stay hidden for years - Dormancy\" \/>\n<meta property=\"og:description\" content=\"How one relatively harmless strain of a herpes virus bides its time in our bodies.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/projects.nyujournalism.org\/dormancy\/play-dead\/the-sleeping-virus\/\" \/>\n<meta property=\"og:site_name\" content=\"Dormancy\" \/>\n<meta property=\"article:modified_time\" content=\"2015-10-10T14:22:48+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/projects.nyujournalism.org\/dormancy\/wp-content\/uploads\/sites\/3\/hiv-cropped20.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/projects.nyujournalism.org\/dormancy\/play-dead\/the-sleeping-virus\/\",\"url\":\"http:\/\/projects.nyujournalism.org\/dormancy\/play-dead\/the-sleeping-virus\/\",\"name\":\"Herpes viruses can stay hidden for years - 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